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INCB 3284
CAS No. 887401-92-5
INCB 3284( —— )
Catalog No. M32966 CAS No. 887401-92-5
INCB 3284 is an orally available, selective and high affinity chemokine receptor 2 (CCR2) antagonist that inhibits monocyte chemotactic protein 1 from interacting with hCCR2.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 48 | Get Quote |
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| 10MG | 77 | Get Quote |
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| 25MG | 126 | Get Quote |
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| 50MG | 180 | Get Quote |
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| 100MG | 266 | Get Quote |
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| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameINCB 3284
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NoteResearch use only, not for human use.
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Brief DescriptionINCB 3284 is an orally available, selective and high affinity chemokine receptor 2 (CCR2) antagonist that inhibits monocyte chemotactic protein 1 from interacting with hCCR2.
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DescriptionINCB 3284 is a potent, selective and orally bioavailable human CCR2 antagonist, inhibiting monocyte chemoattractant protein-1 binding to hCCR2, with an IC50 of 3.7 nM. INCB 3284 can be used in the research of acute liver failure.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayAutophagy
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TargetCCR
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RecptorCCR
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Research Area——
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Indication——
Chemical Information
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CAS Number887401-92-5
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Formula Weight520.54
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Molecular FormulaC26H31F3N4O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : ≥ 83.3 mg/mL (160.03 mM) H2O : < 0.1 mg/mL (insoluble)
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SMILESCOc1ccc(cn1)[C@@]1(O)CC[C@@H](CC1)N1CC[C@H](C1)NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Xue CB, et al. Discovery of INCB3284, a Potent, Selective, and Orally Bioavailable hCCR2 Antagonist. ACS Med Chem Lett. 2011 Mar 31;2(6):450-4.?
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